• Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients 

      Pihlstrøm, Hege; Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Gatti, Francesca; Hammarström, Clara Louise; Kasprzycka, Monika; Wang, Junbai; Haraldsen, Guttorm; Mjøen, Geir; Dahle, Dag Olav; Midtvedt, Karsten; Eide, Ivar Anders; Hartmann, Anders; Holdaas, Hallvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-16)
      Following a successful renal transplantation circulating markers of inflammation may remain elevated, and systemic inflammation is associated with worse clinical outcome in renal transplant recipients (RTRs). Vitamin D-receptor (VDR) activation is postulated to modulate inflammation and endothelial function. We aimed to explore if a synthetic vitamin D, paricalcitol, could influence systemic ...
    • Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients 

      Smedbråten, Julia; Mjøen, Geir; Hartmann, Anders; Åsberg, Anders; Rollag, Halvor; Mollnes, Tom Eirik; Sandvik, Leiv; Fagerland, Morten W.; Thiel, Steffen; Sagedal, Solbjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-18)
      Background: Higher incidence of malignancy and infectious diseases in kidney transplant recipients is related to immunosuppressive treatment after transplantation and the recipient’s native immune system. The complement system is an essential component of the innate immunity. The aim of the present study was to investigate the association of effector molecules of the lectin complement pathway with ...
    • One-year protocol biopsies from ABO-incompatible renal allografts compared with a matched cohort of ABO-compatible allografts 

      Dörje, Christina; Mjøen, Geir; Strøm, Erik Heyerdahl; Holdaas, Hallvard; Jenssen, Trond Geir; Øyen, Ole; Akkøk, Cigdem Ahaein; Småstuen, Milada C; Midtvedt, Karsten; Reisæter, Anna Varberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-21)
      Abstract: Introduction: Early acute antibody-mediated rejection (ABMR) occurs more frequently in ABO-incompatible (ABOi) than in ABO-compatible (ABOc) kidney transplantation. This could lead to increased inflammation/scarring in the ABOi grafts. Protocol biopsy data in ABOi kidney recipients are scarce.<p> <p>Methods: A single-center retrospective matched cohort study was conducted. Eighty ...